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It does not have any absolute contraindications, except for severe renal failure.41 In smokers who have previously used standard dose varenicline and who have been unsuccessful, or in those in whom standard dose varenicline does not control the symptoms of withdrawal syndrome, it is recommended to prolong the treatment up to 6 months

Smoking tobacco causes more than 7 million deaths worldwide each year, contributes to nearly one-third of all cancer deaths, and costs the U.S

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Monteil MA, Joseph G, Chang Kit C, Wheeler G, Antoine RM (2004) Smoking at home is strongly associated with symptoms of asthma and rhinitis in children of primary school age in Trinidad and Tobago